Found 48 matching trials
JZP458 - Recombinant Erwinia Asparaginase for Treatment of ALL / LBL Patients With Hypersensitivity to E. Coli-derived Asparaginase
N/AThis study is an Expanded Access Protocol (EAP) of JZP458 in participants w...
Status
Approved For Marketing
Location
Multiple Locations
Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL)
PHASE1H. Lee Moffitt Cancer Center and Research Institute will be the Sunshine Pr...
Location
Holtz Children's Hospital University of Miami Miller School of Medicine
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia
PHASE3This phase III trial studies how well blinatumomab works in combination wit...
Status
Active Not Recruiting
Location
Children's Hospital of Alabama
Erwinase Master Treatment Protocol
N/AThe purpose of this study is to make Erwinase available to patients with ac...
Status
No Longer Available
Location
Multiple Locations
A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia
PHASE2The overall aim of this study is to determine if epigenetic priming with a ...
Status
Active Not Recruiting
Location
Children's Hospital of Central California
EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)
PHASE1An experimental drug called EZN-3042 targets survivin, a protein expressed ...
Location
Childrens Hospital Los Angeles
Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
PHASE3The primary objective of this study (TOTXVI) is to compare the clinical ben...
Location
St. Jude Children's Research Hospital
Treatments Being Tested
Prednisone, Vincristine, Daunorubicin, PEG-L-asparaginase, Erwinia L-asparaginase, Doxorubicin, Cyclophosphamide, Cytarabine, ThioguanineClofarabine, Methotrexate, Mercaptopurine, Dexamethasone, Etoposide, Dasatinib Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic Leukemia
PHASE2The main purpose of this study is to find out how well participants with re...
Location
Rady Children's Hospital and Health Center
Treatments Being Tested
Etoposide, cytarabine, vincristine, dexamethasonemethotrexate, teniposide, PEG-asparaginasemitoxantrone, cyclophosphamide, mercaptopurine, vinblastineL-asparaginase, erwinia asparaginasechemotherapy, intrathecal chemotherapy, steroid therapyHematopoietic Stem Cell TransplantNatural Killer (NK) Cell Transplant UPDATE AML: UPdated Disease Monitoring And Treatment for Enhanced Outcomes for Pediatric AML
EARLY_PHASE1This research study investigates the tolerability of substituting two cycle...
Location
Texas Children's Cancer and Hematology Center
Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224)
PHASE1This is a phase I study using the Erwinia form of asparaginase in place of ...
Location
Childrens Hospital Los Angeles